Early and precise diagnosis of leukemia subtypes directly impacts the determination
of optimal treatment strategies and patient survival rates. Traditional
methods often rely on manual microscopic examination of blood and bone marrow
samples, which can be time-consuming and prone to human error. In this
paper, we propose a comprehensive and innovative approach combining the
DenseNet201 and the EfficientNetB3 architectures through the stacking and
weighted average Ensemble techniques to classify six types of Leukemia: Chronic
Lymphocytic Leukemia (CLL), Chronic Myeloid Leukemia (CML), Acute Lymphoblastic
Leukemia (L1 and L2), and Acute Myeloid Leukemia (M0 and M1).
The four models were trained and evaluated on a diverse dataset of microscopic
images. The Ensemble techniques demonstrated superior performance against
the standalone models, achieving a peak precision of 99.56%, further proving
the efficiency and reliability of deep learning architectures in the development of
accurate, and reliable computer-aided diagnosis systems for automated leukemia
classification, that can reduce the workload on pathologists.